Il est disponible sous forme de comprimГ© oral de 100 mg, de comprimГ© oral de 400 mg et de suppositoire oral de 200 mg. En 1997, le Journal of the American Medical Association a rapportГ© que bien que le modafinil ait Г©tГ© Г©tudiГ© pendant des dГ©cennies et utilisГ© en dehors des essais cliniques, son utilisation en tant que substance amГ©liorant les performances restait controversГ©e. Le cerveau fonctionne Г l'aide de son niveau de dopamine. Le modafinil semble Г©galement augmenter les niveaux de GABA dans le cortex prГ©frontal et le noyau accumbens chez le rat.
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Le modafinil, Г©galement connu sous le nom de 2-(benzhydrylthio)-N-[(1R)-1-mГ©thyl-2-pyrrolidinyl]acГ©tamide, est une poudre cristalline blanche Г blanc cassГ©. Le modafinil est disponible aux Г‰tats-Unis depuis 1998. Le modafinil a Г©galement Г©tГ© utilisГ©, hors AMM, pour l'amГ©lioration cognitive. Aux Г‰tats-Unis, il est classГ© comme substance contrГґlГ©e de l'annexe IV, ce qui signifie que sa lГ©galitГ© est limitГ©e aux pharmaciens titulaires d'une licence spГ©ciale.
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