Le trouble du sommeil lié au travail posté se caractérise par une somnolence diurne excessive et une tendance réduite à dormir la nuit. En effet, il faut plusieurs heures pour que le modafinil soit absorbé et les niveaux de vigilance maximaux ne sont atteints qu'après environ 4 heures après l'administration, ce qui correspond à peu près au temps qu'il faudrait pour se réveiller et s'endormir. Développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon, le modafinil est prescrit en France depuis 1994. Le modafinil a été le premier stimulant de "troisième génération" découvert.
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La dose initiale et d'entretien approuvГ©e est de 200 mg ou 400 mg par jour. Le CDC a signalГ© qu'aucun cas de convulsion n'a Г©tГ© signalГ© dans les essais cliniques. La FDA a approuvГ© pour la premiГЁre fois le modafinil pour les troubles du sommeil liГ©s au travail postГ© en 2002 et a approuvГ© l'utilisation du modafinil comme traitement de la narcolepsie en 2004. Le modafinil est structurellement similaire Г l'amphГ©tamine et Г la mГ©thamphГ©tamine, mais il agit beaucoup plus lentement.
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