La demi-vie du modafinil est plus élevée chez les personnes atteintes de cirrhose hépatique et présentant des variations génétiques des enzymes clés qui métabolisent le médicament. L'équipe de Korsakov a découvert que le modafinil améliorait le sommeil et les performances chez les patients souffrant de troubles du sommeil et de l'éveil, en particulier ceux souffrant de narcolepsie. Dix des participants ont reçu du modafinil et onze ont reçu un placebo. Le modafinil dans ce dernier rôle est connu sous le nom de "modafinil du matin" et est largement utilisé par les travailleurs de quarts dans l'industrie technologique nord-américaine.
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Ces amГ©liorations se produisent dans les rГ©gions du cerveau qui favorisent l'Г©veil, mais n'activent pas les zones du cerveau qui favorisent le rГЄve ou d'autres rГЄves. Les rГ©actions allergiques peuvent inclure une Г©ruption cutanГ©e, des dГ©mangeaisons, des frissons, un essoufflement, des saignements ou des ecchymoses inhabituels et des difficultГ©s respiratoires. En tant que traitement mГ©dical, le modafinil peut ГЄtre considГ©rГ© comme agissant via deux mГ©canismes principaux. C'est pourquoi ces types de mГ©dicaments sont communГ©ment appelГ©s psychotropes, car ils affectent gГ©nГ©ralement l'humeur, la pensГ©e et le comportement, ainsi que la capacitГ© Г mГ©moriser des choses ou Г acquГ©rir de nouvelles compГ©tences.
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