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Le médicament a été signalé pour la première fois à l'Office américain des brevets en 1972 à Christian de Machholz, qui a ensuite cédé ses droits à la société française Lafon Laboratories. Il augmente l'efficacité de la dopamine dans le cerveau et diminue également la vitesse à laquelle la dopamine est réabsorbée par le cerveau. Le modafinil peut également être utilisé pour traiter les patients adultes atteints d'autisme et de schizophrénie, bien que cet effet soit controversé. Il est largement utilisé comme traitement des troubles du sommeil liés au travail posté.

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Le modafinil est un agent modulateur de la dopamine. Le modafinil agit par un mГ©canisme qui peut ГЄtre diffГ©rent de celui du mГ©thylphГ©nidate et d'autres stimulants. Le modafinil a la capacitГ© d'augmenter l'Г©veil et la mГ©moire de travail.

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