Ce médicament n'est pas une ordonnance pour le TDA/TDAH. Modafinil a été développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. Aux États-Unis, l'utilisation d'ordonnances devrait augmenter de 265 % entre 2011 et 2015. Le modafinil et l'armodafinil favorisent l'éveil en augmentant le temps passé éveillé et en diminuant le temps passé en sommeil lent. Les preuves provenant d'autres classes de stimulants indiquent que la modulation des systèmes noradrénergique et dopaminergique est le mécanisme d'action des stimulants.
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Avec une prescription en tant que substance contrГґlГ©e de l'annexe IV aux Г‰tats-Unis et en Europe, le modafinil est disponible via un processus de prescription uniquement. Plus d'une douzaine de personnes utilisant du modafinil en plus de mГ©dicaments pour le TDAH n'ont signalГ© aucun dГ©veloppement de dГ©pendance aprГЁs 17 semaines. On pense que le modafinil agit dans les ganglions de la base, le В« standard В» du systГЁme nerveux central, ce qui amГ©liore l'Г©veil.
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