Provigil

En 1980, Ciba a embauchГ© une sociГ©tГ© de dГ©veloppement de mГ©dicaments basГ©e Г  Paris, Actelion, pour travailler avec elle sur la crГ©ation d'un substitut plus rГ©sistant Г  la pollution que le Modafinil. On ne sait pas s'il existe un effet cliniquement significatif du modafinil sur la tempГ©rature corporelle, la respiration ou le pouls. Le modafinil est gГ©nГ©ralement pris Г  un moment donnГ© entre l'heure du coucher et environ une heure avant d'aller dormir.

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Le modafinil est l'isomГЁre optique dextrogyre de l'amphГ©tamine et est chimiquement une phГ©nylisopropylamine. Les effets bГ©nГ©fiques sont restГ©s par rapport au placebo aprГЁs deux semaines de traitement. Pour la narcolepsie, Provigil s'est avГ©rГ© augmenter l'Г©veil sans diminuer la durГ©e du sommeil en supprimant le temps passГ© en sommeil paradoxal.

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