Certaines Г©tudes suggГЁrent un large index thГ©rapeutique, bien que les effets indГ©sirables puissent s'aggraver Г des doses plus Г©levГ©es. Bien que certaines Г©tudes suggГЁrent que les effets du modafinil durent jusqu'Г 12 heures, la plupart des gens devront le prendre plusieurs fois par jour pour voir son plein effet. Au Royaume-Uni, il peut ГЄtre obtenu auprГЁs d'une pharmacie en tant que mГ©dicament dГ©livrГ© uniquement sur ordonnance sous le nom de marque Modalert. Chez l'adulte, la dose recommandГ©e est de 200 Г 400 mg de modafinil pris une fois par jour, bien que des Г©tudes indiquent que des doses comprises entre 150 et 200 mg de modafinil sont les plus efficaces. Le modafinil a Г©tГ© vendu pour la premiГЁre fois sous le nom d'Alveford-1 en 1994 en France.
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Cela aide Г la transmission du signal et Г la rГ©ponse au stimulus. Certains chercheurs Г©mettent l'hypothГЁse que Modafinil modifie la plasticitГ© synaptique via les actions DA au niveau des rГ©cepteurs DA. La dose initiale est prise Г jeun avant le coucher.
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