Il dГ©tend les muscles des vaisseaux sanguins, permettant au cerveau d'obtenir plus d'oxygГЁne et de sang et, par consГ©quent, de devenir plus alerte. Le modafinil est un composГ© artificiel de deux blocs de construction chimiques, l'amphГ©tamine et le mГ©thylphГ©nidate. Bien qu'il ne soit pas recommandГ© de l'utiliser pendant la grossesse, les femmes enceintes ne doivent pas utiliser le mГ©dicament. Le modafinil, son eutomГЁre, a Г©tГ© approuvГ© pour un usage mГ©dical par la FDA le 13 aoГ»t 1998 et Г©tait auparavant commercialisГ© sous le nom de Provigil aux Г‰tats-Unis, au Canada et au Royaume-Uni.
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Selon certains mГ©decins et dГ©fenseurs des patients, le modafinil peut amГ©liorer la dГ©pendance Г des substances telles que la cocaГЇne et la mГ©thamphГ©tamine chez les personnes Г©galement sujettes Г la dГ©pendance. Le modafinil inhibe la recapture de la norГ©pinГ©phrine et de l'acГ©tylcholine, et amГ©liore Г©galement la libГ©ration de ces neurotransmetteurs par les vГ©sicules synaptiques. Une thГ©orie suggГЁre que cela fonctionne en bloquant la recapture de la dopamine dans les terminaisons nerveuses, augmentant ainsi la concentration de dopamine au niveau de la synapse. Ils ont notГ© que "cette action d'Г©veil sГ©lective du modafinil indique qu'il peut avoir une action spГ©cifique sur les systГЁmes dopaminergiques modulateurs du sommeil". Son mГ©canisme d'action consiste Г augmenter la quantitГ© de sГ©rotonine et de dopamine disponible dans le cerveau en inhibant les mГ©canismes de recapture de la sГ©rotonine et de la dopamine.
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